The wind and fire wheels under Nezha's feet represent skin organoids, while Ao Bing represents the skin, and the monster symbolizes frostbite. The monster (frostbite) spews weapons (monocytes, macrophages, fibroblasts, myofibroblasts, and abnormal extracellular matrix) targeting Ao Bing (skin). However, Nezha, stepping on the wind and fire wheels (skin organoids), plays a crucial role by regulating epidermal stem cells, reducing inflammation and abnormal collagen deposition. With Nezha's help, Ao Bing is rescued from the frozen sea. Ultimately, Nezha and Ao Bing (spiritual pearl and magic pill) collaborate to defeat the monster (frostbite). The excellent therapeutic effects of skin organoids offer a promising new approach for treating skin ulcers caused by various factors.