2021, Volume 12, Issue 6
Recent studies revealed the cross-talk between RNA modifications and chromatin, which provides multitudinous ways for tuning the chromatin state and transcription activities. Chen et al. demonstrated that in mouse embryonic stem cells (ESCs), the nuclear m6A reader YTHDC1 recognizes the m6A-marked LINE1 RNA scaffold on chromatin and further promotes the formation of the LINE1-NCL-KAP1 complex, which ensures the sufficient KAP1-mediated H3K9me3 installation on specific targets including 2-cellrelated retrotransposons. The LINE1-regulators complex works like a zipper which realizes the RNA-chromatin crosstalk and contributes to the ESC maintenance and embryonic development potency.