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Bioinformatics: One Step Ahead. After understanding where bioinformatics takes us and what problems it solves, Chinese scientists exert to apply existing methodologies and tools by pioneers to biomedical research and develop new platforms in the field. Since 2003, the number of bioinformatics (and computational biology) publications from China indexed in PubMed at NCBI has been significantly increased; particularly the number of bioinformatics publications from China is growing faster than worldwide and the percentage of bioinformatics publications among all PubMed publications is greater in China than worldwide. Several papers in this issue focus on exploring molecular networks, which is essential to bridge omics data, gene functions, and systems biology, and detect gene mutations in humans and pathogenic bacteria in seafood, both of which are interesting applications of current bioinformatics. More importantly, opportunities and challenges are emerging in this promising field——how to stay one step ahead of the development of bioinformatics in China, comparing to experimental biology?
NEWS AND VIEWS
Cryptomycota: the missing link p161
Krishna Bolla, Elizabeth Jane Ashforth
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PERSPECTIVE
A phylum level analysis reveals lipoprotein biosynthesis to be a fundamental property of bacteria p163
Iain C. Sutcliffe, Dean J. Harrington, Matthew I.Hutchings
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RECOLLECTION
Cornell University and modern biology in China p171
Ming Li
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REVIEWS
Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis p173
Yuan Yuan, Peng Li, Jing Ye
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Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer development p182
Jijing Luo, Xiaoqi Liu
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COMMUNICATION
An examination of the OMIM database for associating mutation to a consensus reference sequence p198
Zuofeng Li, Beili Ying, Xingnan Liu, Xiaoyan Zhang, Hong Yu
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Development of a real time PCR assay for rapid detection of Vibrio parahaemolyticus from seafood
p204
Bin Liu, Xiaohua He, Wanyi Chen, Shuijing Yu, Chunlei Shi, Xiujuan Zhou, Jing Chen, Dapeng Wang, Xianming Shi
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RESEARCH ARTICLES
System approaches reveal the molecular networks involved in neural stem cell differentiation p213
Kai Wang, Haifeng Wang, Jiao Wang, Yuqiong Xie, Jun Chen, Huang Yan, Zengrong Liu, Tieqiao Wen
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BioNetSim: a Petri net-based modeling tool for simulations of biochemical processes p225
Junhui Gao, Li Li, Xiaolin Wu, Dong-Qing Wei
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Calculating pH-dependent free energy of proteins by using Monte Carlo protonation probabilities of ionizable residues p230
Qiang Huang, Andreas Herrmann
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ERRATUM
Crystal structure of human Gadd45γ reveals an active dimer p239
Wenzheng Zhang, Sheng Fu, Xuefeng Liu, Xuelian Zhao, Wenchi Zhang, Wei Peng, Congying Wu, Yuanyuan Li, Xuemei Li, Mark Bartlam, Zong-Hao Zeng, Qimin Zhan, Zihe Rao
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Emerging technology of in situ cell free expression protein microarrays p239
Amita Nand, Anju Gautam, Javier Batista Pérez, Alejandro Merino, Jinsong Zhu
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Featured articles
Review: Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis
Yuan Yuan, Peng Li, Jing Ye
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Research article: System approaches reveal the molecular networks involved in neural stem cell differentiation
Kai Wang, Haifeng Wang, Jiao Wang, Yuqiong Xie, Jun Chen, Huang Yan, Zengrong Liu, Tieqiao Wen
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Featured articles
Review: Converted neural cells: induced to a cure?
Weiqi Zhang, Shunlei Duan, Ying Li, Xiuling Xu, Jing Qu, Weizhou Zhang, Guang-Hui Liu
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Research article: Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars
Hsiu-Chien Chan, Yueming Zhu, Yumei Hu, Tzu-Ping Ko, Chun-Hsiang Huang, Feifei Ren, Chun-Chi Chen, Yanhe Ma, Rey-Ting Guo, Yuanxia Sun
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Featured articles
Review: Horizontal transfer of microRNAs: molecular mechanisms and clinical applications
Xi Chen, Hongwei Liang, Junfeng Zhang, Ke Zen, Chen-Yu Zhang
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Research article:A novel xeno-free and feeder-cell-free system for human pluripotent stem cell culture
Qihui Wang, Xiaoning Mou, Henghua Cao, Qingzhang Meng, Yanni Ma, Pengcheng Han, Junjie Jiang, Hao Zhang, Yue Ma
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Featured articles
Review: Protein-protein complexation in bioluminescence
Maxim S. Titushin, Yingang Feng, John Lee, Eugene S. Vysotski, Zhi-Jie Liu
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Research article: Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines
Chunling Xuan, Yi Shi, Jianxun Qi, Wei Zhang, Haixia Xiao, George F. Gao
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