Volume 12 Issue 10
Sep.  2021
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Xuwen Li, Zijian Zhang, Xinlong Luo, Jacob Schrier, Andrew D. Yang, Tao P. Wu. The exploration of N6-deoxyadenosine methylation in mammalian genomes[J]. Protein&Cell, 2021, 12(10): 756-768. doi: 10.1007/s13238-021-00866-3
Citation: Xuwen Li, Zijian Zhang, Xinlong Luo, Jacob Schrier, Andrew D. Yang, Tao P. Wu. The exploration of N6-deoxyadenosine methylation in mammalian genomes[J]. Protein&Cell, 2021, 12(10): 756-768. doi: 10.1007/s13238-021-00866-3

The exploration of N6-deoxyadenosine methylation in mammalian genomes

doi: 10.1007/s13238-021-00866-3

We thank Dr. Andrew Z. Xiao of the Yale University and Dr. Hongjie Li of Baylor College of Medicine for comments on the manuscript. Tao P. Wu is a CPRIT scholar for cancer research. This work is supported by grants from CPRIT (RR180072) and Rivkin Center Scientific Scholar Award.

  • Received Date: 2021-03-03
  • Rev Recd Date: 2021-07-12
  • Publish Date: 2021-09-27
  • N6-methyladenine (N6-mA, m6dA, or 6mA), a prevalent DNA modification in prokaryotes, has recently been identified in higher eukaryotes, including mammals. Although 6mA has been well-studied in prokaryotes, the function and regulatory mechanism of 6mA in eukaryotes are still poorly understood. Recent studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biological processes, from transposable-element suppression to environmental stress response. Here, we review the significant advances in methodology for 6mA detection and major progress in understanding the regulation and function of this non-canonical DNA methylation in eukaryotes, predominantly mammals.
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