Volume 12 Issue 5
May  2021
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Tzu-Lung Lin, Chia-Chen Lu, Wei-Fan Lai, Ting-Shu Wu, Jang-Jih Lu, Young-Mao Chen, Chi-Meng Tzeng, Hong-Tao Liu, Hong Wei, Hsin-Chih Lai. Role of gut microbiota in identification of novel TCM-derived active metabolites[J]. Protein&Cell, 2021, 12(5): 394-410. doi: 10.1007/s13238-020-00784-w
Citation: Tzu-Lung Lin, Chia-Chen Lu, Wei-Fan Lai, Ting-Shu Wu, Jang-Jih Lu, Young-Mao Chen, Chi-Meng Tzeng, Hong-Tao Liu, Hong Wei, Hsin-Chih Lai. Role of gut microbiota in identification of novel TCM-derived active metabolites[J]. Protein&Cell, 2021, 12(5): 394-410. doi: 10.1007/s13238-020-00784-w

Role of gut microbiota in identification of novel TCM-derived active metabolites

doi: 10.1007/s13238-020-00784-w

We would like to express our thankfulness for funding provided from CORPD1F0013 and CORPD1J0052 from Chang Gung Memorial Hospital, Microbiota Research Center from Chang Gung University, and the Research Center for Emerging Viral Infections from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project (MOST109-2634- F-182-001, 109-2320-B-030-010, 109-2327-B-182-001).

  • Received Date: 2020-03-13
  • Rev Recd Date: 2020-05-29
  • Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.
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