2021 Vol. 12, No. 3
Paving the way towards cancer: 11q13 amplicon fuels cancer cells with SHANK2 to dislodge HIPPO. Certain oncogenes are amplified in cancer cells to promote tumorigenesis. Xu et al. demonstrated that amongst genes on the 11q13 tumor amplicon, SHANK2 is the most frequently amplified gene in human cancers and acts as an oncogene. SHANK2 is a novel and evlutionarily conserved regulator of HIPPO pathway. Through competitive binding, overexpressed SHANK2 displaces LATS kinase from its activator, thereby librating YAP to promote tumor formation.