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1
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Puping Liang, Yanwen Xu, Xiya Zhang, Chenhui Ding, Rui Huang, Zhen Zhang, Jie Lv, Xiaowei Xie, Yuxi Chen, Yujing Li, Ying Sun, Yaofu Bai, Zhou Songyang, Wenbin Ma, Canquan Zhou, Junjiu Huang
2015, 6(5): 363-372. doi: 10.1007/s13238-015-0153-5
2
Correction of β-thalassemia mutant by base editor in human embryos
Puping Liang, Chenhui Ding, Hongwei Sun, Xiaowei Xie, Yanwen Xu, Xiya Zhang, Ying Sun, Yuanyan Xiong, Wenbin Ma, Yongxiang Liu, Yali Wang, Jianpei Fang, Dan Liu, Zhou Songyang, Canquan Zhou, Junjiu Huang
2017, 8(11): 811-822. doi: 10.1007/s13238-017-0475-6
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Questions about NgAgo
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2016, 7(12): 913-915. doi: 10.1007/s13238-016-0343-9
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Current progress in innovative engineered antibodies
R. Strohl William
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The regulation of TGF-β/SMAD signaling by protein deubiquitination
Juan Zhang, Xiaofei Zhang, Feng Xie, Zhengkui Zhang, Hans van Dam, Long Zhang, Fangfang Zhou
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T-cell receptor-engineered T cells for cancer treatment: current status and future directions
Yu Ping, Chaojun Liu, Yi Zhang
2018, 9(3): 254-266. doi: 10.1007/s13238-016-0367-1
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Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo
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Julian Savulescu, Jonathan Pugh, Thomas Douglas, Christopher Gyngell
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Advancing chimeric antigen receptor T cell therapy with CRISPR/Cas9
Jiangtao Ren, Yangbing Zhao
2017, 8(9): 634-643. doi: 10.1007/s13238-017-0410-x
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Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
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The crystal structure of Zika virus helicase: basis for antiviral drug design
Hongliang Tian, Xiaoyun Ji, Xiaoyun Yang, Wei Xie, Kailin Yang, Cheng Chen, Chen Wu, Heng Chi, Zhongyu Mu, Zefang Wang, Haitao Yang
2016, 7(6): 450-454. doi: 10.1007/s13238-016-0275-4
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Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template
Zhili Rong, Shengyun Zhu, Yang Xu, Xuemei Fu
2014, 5(4): 258-260. doi: 10.1007/s13238-014-0032-5
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Human gut microbiota: the links with dementia development
Rashad Alkasir, Jing Li, Xudong Li, Miao Jin, Baoli Zhu
2017, 8(2): 90-102. doi: 10.1007/s13238-016-0338-6
16
The hierarchy quorum sensing network in Pseudomonas aeruginosa
asmine Lee, Lianhui Zhang
2015, 6(1): 26-41. doi: 10.1007/s13238-014-0100-x
17
Urgency to rein in the gene-editing technology
Xiaoxue Zhang
2015, 6(5): 313-313. doi: 10.1007/s13238-015-0161-5
18
Driver mutations of cancer epigenomes
David M. Roy, Logan A. Walsh, Timothy A. Chan
2014, 5(4): 265-296. doi: 10.1007/s13238-014-0031-6
19
Jian-Kang Liu: A pioneer of sex determination studies in vertebrates
Li Zhou, Jian-Fang Gui
2016, 7(1): 1-3. doi: 10.1007/s13238-015-0232-7
20
In vitro expression and analysis of the 826 human G protein-coupled receptors
Xuechen Lv, Junlin Liu, Qiaoyun Shi, Qiwen Tan, Dong Wu, John J. Skinner, Angela L. Walker, Lixia Zhao, Xiangxiang Gu, Na Chen, Lu Xue, Pei Si, Lu Zhang, Zeshi Wang, Vsevolod Katritch, Zhi-jie Liu, Raymond C. Stevens
2016, 7(5): 325-337. doi: 10.1007/s13238-016-0263-8

Current Issue

November, 2019

Volume 10, Issue 11

Pages 779-853

About the cover

While p53 is widely considered as a tumor suppressor that induces cell apoptosis upon severe DNA damage, Ge Y et al.report that p53 acts to promote the proliferation of ALT (telomerase negative) cancer cells by suppressing the apoptosis through activation of AKT.The pro-or anti-apoptosis function of p53 is dependent upon its concentration in cells. ALT cancers express a low level of p53 that is insufficient to initiate the transcription of apoptosis-related genes, but is able to stimulate the expression of mTORC2 that activates AKT. Therefore, inhibition of p53 and/or AKT has a potential as therapeutics for specifically targeting ALT cancers that bear a high load of apoptotic stress.

Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang Beijing 100101, China

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