Latest Articles

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma
Xiaoming Dai, Jing Liu, Wenyi Wei
 doi: 10.1007/s13238-020-00721-x
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids
Bing Zhao, Chao Ni, Ran Gao, Yuyan Wang, Li Yang, Jinsong Wei, Ting Lv, Jianqing Liang, Qisheng Zhang, Wei Xu, Youhua Xie, Xiaoyue Wang, Zhenghong Yuan, Junbo Liang, Rong Zhang, Xinhua Lin
 doi: 10.1007/s13238-020-00718-6
BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy
Ermin Li, Xiuya Li, Jie Huang, Chen Xu, Qianqian Liang, Kehan Ren, Aobing Bai, Chao Lu, Ruizhe Qian, Ning Sun
 doi: 10.1007/s13238-020-00713-x
Dysregulation of circadian rhythms associates with cardiovascular disorders. It is known that deletion of the core circadian gene Bmal1 in mice causes dilated cardiomyopathy. However, the biological rhythm regulation system in mouse is very different from that of humans. Whether BMAL1 plays a role in regulating human heart function remains unclear. Here we generated a BMAL1 knockout human embryonic stem cell (hESC) model and further derived human BMAL1 deficient cardiomyocytes. We show that BMAL1 deficient hESC-derived cardiomyocytes exhibited typical phenotypes of dilated cardiomyopathy including attenuated contractility, calcium dysregulation, and disorganized myofilaments. In addition, mitochondrial fission and mitophagy were suppressed in BMAL1 deficient hESC-cardiomyocytes, which resulted in significantly attenuated mitochondrial oxidative phosphorylation and compromised cardiomyocyte function. We also found that BMAL1 binds to the E-box element in the promoter region of BNIP3 gene and specifically controls BNIP3 protein expression. BMAL1 knockout directly reduced BNIP3 protein level, causing compromised mitophagy and mitochondria dysfunction and thereby leading to compromised cardiomyocyte function. Our data indicated that the core circadian gene BMAL1 is critical for normal mitochondria activities and cardiac function. Circadian rhythm disruption may directly link to compromised heart function and dilated cardiomyopathy in humans.
The expanded development and application of CRISPR system for sensitive nucleotide detection
Fengjing Jia, Xuewen Li, Chao Zhang, Xueming Tang
 doi: 10.1007/s13238-020-00708-8
Memory T cells: strategies for optimizing tumor immunotherapy
Qingjun Liu, Zhongjie Sun, Ligong Chen
 doi: 10.1007/s13238-020-00707-9
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in (ex) vivo that, might be applicable in clinical practice.
Recent advances in CRISPR research
Baohui Chen, Yuyu Niu, Haoyi Wang, Kejian Wang, Hui Yang, Wei Li
 doi: 10.1007/s13238-020-00704-y
Single-cell transcriptomic analysis of adult mouse pituitary reveals sexual dimorphism and physiologic demand-induced cellular plasticity
Yugong Ho, Peng Hu, Michael T. Peel, Sixing Chen, Pablo G. Camara, Douglas J. Epstein, Hao Wu, Stephen A. Liebhaber
 doi: 10.1007/s13238-020-00705-x
Pioneer of burn medicine in China: Professor Li Ao and “Li Ao spirit”
Yaling Liao, Quaming Zou, Jiang Gu
 doi: 10.1007/s13238-020-00703-z
Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
Weiwei Jiang, Fangfang Cai, Huangru Xu, Yanyan Lu, Jia Chen, Jia Liu, Nini Cao, Xiangyu Zhang, Xiao Chen, Qilai Huang, Hongqin Zhuang, Zi-Chun Hua
 doi: 10.1007/s13238-020-00701-1
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation
Jing Tang, Bowei Zhou, Melanie J. Scott, Linsong Chen, Dengming Lai, Erica K. Fan, Yuehua Li, Qiang Wu, Timothy R. Billiar, Mark A. Wilson, Ping Wang, Jie Fan
 doi: 10.1007/s13238-019-00679-5
Correction to: Core transcriptional signatures of phase change in the migratory locust
Pengcheng Yang, Li Hou, Xianhui Wang, Le Kang
 doi: 10.1007/s13238-019-00688-4
Qi Fang: Affective interweave with patients
Tanping Fu, Wenli Duan, Mingyan Chen, Shuyang Zhang
 doi: 10.1007/s13238-019-00667-9
Kuo-Hua Sun: The founder of physiologic psychology and child psychology in China
Yimeng Wang, Yanyan Qian
 doi: 10.1007/s13238-019-00666-w
Professor Haowen Xu: The founder of exercise biochemistry in China
Wei Gong, Yijing Shen, Jiaqi Bao, Yike Ying, Han Zhou, Zhifeng Wu
 doi: 10.1007/s13238-019-00663-z
Shu-szi Sin: A Chinese pioneer biologist, ancient agronomist, and educator
Qun Xie, Yan-ping Cheng, Lei Fu
 doi: 10.1007/s13238-019-00657-x
Professor Cuifen Huang: a great molecular geneticist and the founder of genetic engineering in China
Wei Gong, Leyi Cui, Yike Ying, Yijing Shen, Jiaqi Bao
 doi: 10.1007/s13238-019-0620-5
Correction to: Developing potent PROTACs tools for selective degradation of HDAC6 protein
Zixuan An, Wenxing Lv, Shang Su, Wei Wu, Yu Rao
 doi: 10.1007/s13238-019-0613-4
Professor Li-Pin. King: a famous physiologist in China
Wei Gong, Fangfang Wang, Yike Ying
 doi: 10.1007/s13238-018-0582-z
Retraction Note to: DDB1 and Cul4 are necessary for gene silencing and heterochromatin formation at pericentromeric regions in Neurospora
Yingqiong Cao, Jicheng Wei, Silu Yang, Jinquan Sun, Hui Xu, Ying Wang, Yuanbiao Zhao, Qun He
 doi: 10.1007/s13238-014-0079-3
RETRACTED ARTICLE: DDB1 and Cul4 are necessary for gene silencing and heterochromatin formation at pericentromeric regions in Neurospora
Yingqiong Cao, Jicheng Wei, Silu Yang, Jinquan Sun, Hui Xu, Ying Wang, Yuanbiao Zhao, Qun He
 doi: 10.1007/s13238-014-0067-7
Current issue
  • ISSN1674-800X
  • EISSN1674-8018
  • IF (2019) 10.164

Microbiota and Human Health

May 2018
Volume 9
Issue 5
pp: 395-510

Metabolism and Disease

May 2018
Volume 9
Issue 2
pp: 141-237

Therapeutic Antibodies

May 2018
Volume 9
Issue 1
pp: 1-139


Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang Beijing 100101, China

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