2018.9(1): 1-140

EDITORIAL

“Magic Bullets” at the center stage of immune therapy: a special issue on therapeutic antibodies     p1

Zhiqiang An

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REVIEWS

In vitro-engineered non-antibody protein therapeutics     p3

Rudo Simeon, Zhilei Chen

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Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins      p15

Liming Liu

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Antibody-drug conjugates: recent advances in conjugation and linker chemistries      p33

Kyoji Tsuchikama, Zhiqiang An

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Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and effi cacy     p47

Yusuke Mimura, Toshihiko Katoh, Radka Saldova, Roisin O’Flaherty, Tomonori Izumi, Yuka Mimura-Kimura, Toshiaki Utsunomiya, Yoichi Mizukami, Kenji Yamamoto, Tsuneo Matsumoto, Pauline M. Rudd

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IgG Fc engineering to modulate antibody effector functions     p63

Xinhua Wang, Mary Mathieu, Randall J. Brezski

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Current progress in innovative engineered antibodies      p74

Xin Wang, Zhiqiang An, Wenxin Luo, Ningshao Xia, Qinjian Zhao

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Molecular and functional analysis of monoclonal antibodies in support of biologics development      p86

William R. Strohl

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RESEARCH ARTICLE

Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig      p121

Philip D. Bardwell, Matthew M. Staron, Junjian Liu, Qingfeng Tao, Susanne Scesney, Gail Bukofzer, Luis E. Rodriguez, Chee-Ho Choi, Jennifer Wang, Qing Chang, Feng Dong, Cherrie Donawho, Jieyi Wang, Christine M. Grinnell, Edit Tarcsa, Charles Hutchins, Tariq Ghayur, Jijie Gu

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LETTERS

A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys      p130

Ciming Kang, Lin Xia, Yuanzhi Chen, Tianying Zhang, Yiwen Wang, Bing Zhou, Min You, Quan Yuan, Chi-Meng Tzeng, Zhiqiang An, Wenxin Luo, Ningshao Xia

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Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab      p135

Shuguang Tan, Kefang Liu, Yan Chai, Catherine W.-H. Zhang, Shan Gao, George F. Gao, Jianxun Qi

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